Abstract
Human histocompatibility leukocyte antigen (HLA)-G is an MHC class lb molecule that has been proposed to regulate immune responses during pregnancy. One of the possible mechanisms of that modulation is based on its interaction with immunoglobulin-like transcript (ILT) receptors. In this study, we show that HLA-G modifies the function of murine dendritic cells via interactions with the paired immunoglobulin-like inhibitory receptor, a homologue of the human inhibitory receptor ILT4. Triggering of the immune inhibitory receptors resulted in prolongation of allogeneic graft survival. This demonstration forms the basis for exploring and exploiting HLA-G molecules and immune inhibitory receptors in the development of a new therapeutic strategy to improve allogeneic graft survival.
Original language | English (US) |
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Pages (from-to) | 2418-2426 |
Number of pages | 9 |
Journal | European Journal of Immunology |
Volume | 32 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2002 |
Keywords
- Dendritic cell
- HLA-G
- Hyporesponsiveness
- Immune inhibitory receptor
- Transgenic mouse
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology