Homocysteine and age‐related central nervous system diseases: Role of inflammation

Amany Tawfik, Nehal M. Elsherbiny, Yusra Zaidi, Pragya Rajpurohit

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Hyperhomocysteinemia (HHcy) is remarkably common among the aging population. The relation between HHcy and the development of neurodegenerative diseases, such as Alz-heimer’s disease (AD) and eye diseases, and age‐related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. Disruption of the blood barrier function of the brain and retina is one of the most important underlying mechanisms associated with HHcy‐induced neurodegenerative and retinal disorders. Impairment of the barrier function triggers inflammatory events that worsen disease pathology. Studies have shown that AD patients also suffer from visual impairments. As an extension of the central nervous system, the retina has been suggested as a prominent site of AD pathology. This review highlights inflammation as a possible underlying mechanism of HHcy‐induced barrier dysfunction and neurovascular injury in aging diseases accompanied by HHcy, focusing on AD.

Original languageEnglish (US)
Article number6259
JournalInternational journal of molecular sciences
Issue number12
StatePublished - Jun 2 2021


  • Age‐related macular degeneration
  • Alzheimer’s disease
  • Diabetic retinopathy
  • Hyperhomocysteinemia
  • Inflammation

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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