TY - JOUR
T1 - Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation
AU - Hamad, Rania
AU - Jayakumar, Calpurnia
AU - Ranganathan, Punithavathi
AU - Mohamed, Riyaz
AU - El-Hamamy, Mahmoud M.I.
AU - Dessouki, Amina A.
AU - Ibrahim, Abdelazim
AU - Ramesh, Ganesan
N1 - Funding Information:
This work was supported by American Heart Association (AHA) Postdoctoral Fellowship to RM and PR, National Institutes of Health (NIH) R01 DK083379 to GR and predoctoral fellowship from Egypt government to RH.
Publisher Copyright:
© 2015 Wiley Publishing Asia Pty Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Cisplatin is a highly effective chemotherapeutic drug used to treat a wide variety of solid tumors. However, its use was limited due its dose-limiting toxicity to the kidney. Currently, there are no therapies available to treat or prevent cisplatin nephrotoxicity. Honey is a naturally occurring complex liquid and widely used in traditional Ayurvedic medicine to treat many illnesses. However, its effect on cisplatin nephrotoxicity is unknown. To determine the role of honey in cisplatin nephrotoxicity, animals were pretreated orally for a week and then cisplatin was administered. Honey feeding was continued for another 3 days. Our results show that animals with cisplatin-induced kidney dysfunction, as determined by increased serum creatinine, which received honey feeding had less kidney dysfunction. Improved kidney function was associated with better preservation of kidney morphology in honey-treated group as compared to the cisplatin alone-treated group. Interestingly, honey feeding significantly reduced cisplatin-induced tubular epithelial cell death, immune infiltration into the kidney as well as cytokine and chemokine expression and excretion as compared to cisplatin treated animals. Western blot analysis shows that cisplatin-induced increase in phosphorylation of NFkB was completely suppressed with honey feeding. In conclusion, honey feeding protects the kidney against cisplatin nephrotoxicity through suppression of inflammation and NFkB activation.
AB - Cisplatin is a highly effective chemotherapeutic drug used to treat a wide variety of solid tumors. However, its use was limited due its dose-limiting toxicity to the kidney. Currently, there are no therapies available to treat or prevent cisplatin nephrotoxicity. Honey is a naturally occurring complex liquid and widely used in traditional Ayurvedic medicine to treat many illnesses. However, its effect on cisplatin nephrotoxicity is unknown. To determine the role of honey in cisplatin nephrotoxicity, animals were pretreated orally for a week and then cisplatin was administered. Honey feeding was continued for another 3 days. Our results show that animals with cisplatin-induced kidney dysfunction, as determined by increased serum creatinine, which received honey feeding had less kidney dysfunction. Improved kidney function was associated with better preservation of kidney morphology in honey-treated group as compared to the cisplatin alone-treated group. Interestingly, honey feeding significantly reduced cisplatin-induced tubular epithelial cell death, immune infiltration into the kidney as well as cytokine and chemokine expression and excretion as compared to cisplatin treated animals. Western blot analysis shows that cisplatin-induced increase in phosphorylation of NFkB was completely suppressed with honey feeding. In conclusion, honey feeding protects the kidney against cisplatin nephrotoxicity through suppression of inflammation and NFkB activation.
KW - Acute kidney injury
KW - Cisplatin
KW - Honey
KW - Inflammation
KW - NFkB
KW - Nephrotoxicity
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U2 - 10.1111/1440-1681.12433
DO - 10.1111/1440-1681.12433
M3 - Article
C2 - 26041312
AN - SCOPUS:84945270392
SN - 0305-1870
VL - 42
SP - 843
EP - 848
JO - Clinical and Experimental Pharmacology and Physiology
JF - Clinical and Experimental Pharmacology and Physiology
IS - 8
ER -