Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Salama A. Salama; Shu Leong Ho; Hui Qun Wang; Jukka Tenhunen; Carola Tilgmann; Ayman Al-Hendy

doi:10.1016/j.fertnstert.2005.12.049

Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Salama A. Salama, Shu Leong Ho, Hui Qun Wang, Jukka Tenhunen, Carola Tilgmann, Ayman Al-Hendy

Translational Research

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Fertility and sterility
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.fertnstert.2005.12.049
State	Published - Jul 2006

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas",

abstract = "Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.",

author = "Salama, {Salama A.} and Ho, {Shu Leong} and Wang, {Hui Qun} and Jukka Tenhunen and Carola Tilgmann and Ayman Al-Hendy",

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AU - Salama, Salama A.

AU - Ho, Shu Leong

AU - Wang, Hui Qun

AU - Tenhunen, Jukka

AU - Tilgmann, Carola

AU - Al-Hendy, Ayman

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AB - Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.

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Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Abstract

ASJC Scopus subject areas

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