TY - JOUR
T1 - How dendritic cells shape atherosclerosis
AU - Koltsova, Ekaterina K.
AU - Ley, Klaus
N1 - Funding Information:
This work was supported by National Institutes of Health HL 58108 and HL55798 to K.L and American Heart Association Fellowship # 10POST4160142-01 to E.K.K.
PY - 2011/11
Y1 - 2011/11
N2 - Atherosclerosis is an inflammatory disease of the arteries, which results in major morbidity and mortality. Immune cells initiate and sustain local inflammation. Here, we focus on how dendritic cell (DC)-mediated processes might be relevant to atherosclerosis. Although only small numbers of DCs are detected in healthy arteries, these numbers dramatically increase during atherosclerosis development. In the earliest fatty streaks, DCs are found next to the vascular endothelium. During plaque growth, new DCs are actively recruited, and their egress from the vessel wall is dampened. In the adventitia next to mature atherosclerotic lesions, tertiary lymphoid organs develop, which also contain DCs. Thus, DCs probably participate in all stages of atherosclerosis from fatty streaks to mature lesions.
AB - Atherosclerosis is an inflammatory disease of the arteries, which results in major morbidity and mortality. Immune cells initiate and sustain local inflammation. Here, we focus on how dendritic cell (DC)-mediated processes might be relevant to atherosclerosis. Although only small numbers of DCs are detected in healthy arteries, these numbers dramatically increase during atherosclerosis development. In the earliest fatty streaks, DCs are found next to the vascular endothelium. During plaque growth, new DCs are actively recruited, and their egress from the vessel wall is dampened. In the adventitia next to mature atherosclerotic lesions, tertiary lymphoid organs develop, which also contain DCs. Thus, DCs probably participate in all stages of atherosclerosis from fatty streaks to mature lesions.
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U2 - 10.1016/j.it.2011.07.001
DO - 10.1016/j.it.2011.07.001
M3 - Review article
C2 - 21835696
AN - SCOPUS:82455219098
SN - 1471-4906
VL - 32
SP - 540
EP - 547
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -