TY - JOUR
T1 - HPV as a model for the development of prophylactic and therapeutic cancer vaccines
AU - Samara, Raed N.
AU - Khleif, Samir N.
PY - 2009/8
Y1 - 2009/8
N2 - HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.
AB - HPV has been linked to many human malignancies and, as such, represents a major public health crisis. The understanding of HPV biology, however, has helped tremendously in developing prophylactic vaccines, which should help in decreasing mortality due to HPV infections. Understanding HPV biology has allowed researchers to use the virus as a model for the development of not only prophylactic vaccines, but also therapeutic ones. The advantages of HPV as a model stem from the limited number of proteins encoded by the HPV genome that can be targeted by vaccines, and also from the restricted expression of certain viral proteins during different stages of infection. In this review, we discuss how HPV can be used as a model for the development of both prophylactic and therapeutic vaccines.
UR - http://www.scopus.com/inward/record.url?scp=70350525547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350525547&partnerID=8YFLogxK
U2 - 10.2174/156652409788970625
DO - 10.2174/156652409788970625
M3 - Review article
C2 - 19689303
AN - SCOPUS:70350525547
SN - 1566-5240
VL - 9
SP - 766
EP - 773
JO - Current Molecular Medicine
JF - Current Molecular Medicine
IS - 6
ER -