Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity

Grace M. Swanson; Molly Estill; Michael P. Diamond; Richard S. Legro; Christos Coutifaris; Kurt T. Barnhart; Hao Huang; Karl R. Hansen; J. C. Trussell; R. Matthew Coward; Heping Zhang; Robert Goodrich; Stephen A. Krawetz

doi:10.1080/15592294.2019.1644880

Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity

Grace M. Swanson, Molly Estill, Michael P. Diamond, Richard S. Legro, Christos Coutifaris, Kurt T. Barnhart, Hao Huang, Karl R. Hansen, J. C. Trussell, R. Matthew Coward, Heping Zhang, Robert Goodrich, Stephen A. Krawetz

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In the United States almost 33% of adults are considered obese (BMI > 30 kg/m²). Both animal models and to a lesser extent human studies, have associated BMI, a measure of obesity, with alterations in sperm DNA methylation and RNAs. Sperm RNAs from the Assessment of Multiple Gestations from Ovarian Stimulation trial, were isolated and sequenced. A Generalized Linear Model identified 487 BMI associated human sperm RNA elements (short exon-sized sequences). They partitioned into four patterns; a continual increase with BMI, increase once obese (BMI>30 kg/m²); a steady decrease with BMI; and decrease once overweight (BMI 25 - 30 kg/m²). Gene Ontology revealed a unique relationship between BMI and transcripts associated with chromosome organization, adipogenesis, cellular stress and obesity-related inflammation. Coregulatory networks linked by Chromatin remodeler cofactors, RNA interactors, Erasers and Writers (CREWs) were uncovered to reveal a hierarchical epigenetic response pathway.

Original language	English (US)
Pages (from-to)	32-46
Number of pages	15
Journal	Epigenetics
Volume	15
Issue number	1-2
DOIs	https://doi.org/10.1080/15592294.2019.1644880
State	Published - Feb 1 2020

Keywords

BMI
CREWs - chromatin remodeler cofactor RNA interactor eraser and writer RNAs
obesity
sperm RNA

ASJC Scopus subject areas

Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/15592294.2019.1644880

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Swanson, G. M., Estill, M., Diamond, M. P., Legro, R. S., Coutifaris, C., Barnhart, K. T., Huang, H., Hansen, K. R., Trussell, J. C., Coward, R. M., Zhang, H., Goodrich, R., & Krawetz, S. A. (2020). Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity. Epigenetics, 15(1-2), 32-46. https://doi.org/10.1080/15592294.2019.1644880

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Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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