Human Immunodeficiency Virus (HIV)

Thomas S. Alexander; Ken S. Rosenthal

doi:10.1016/B978-0-12-818731-9.00184-1

Human Immunodeficiency Virus (HIV)

Thomas S. Alexander, Ken S. Rosenthal

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

HIV is the causative agent of AIDS. Binding of the virus to CD4 positive cells and a chemokine co-receptor initiate infection of myeloid and T cells. This results in a profound decrease in CD4 T cells, loss of cell mediated immune function and occurrence of opportunistic infections. Infection is diagnosed by sequential antibody or molecular assays and the viral infection is treated with multiple anti-retroviral drugs. The infection can be controlled but not eradicated as the virus continues to reside quiescent in the genetic material of a subset of target cells.

Original language	English (US)
Title of host publication	Encyclopedia of Infection and Immunity
Publisher	Elsevier
Pages	123-130
Number of pages	8
Volume	2
ISBN (Electronic)	9780128187319
DOIs	https://doi.org/10.1016/B978-0-12-818731-9.00184-1
State	Published - Jan 1 2022
Externally published	Yes

Keywords

Acquired immunodeficiency syndrome (AIDS)
Anti-retroviral treatment
CD4
gP120/160
Human immunodeficiency virus (HIV)
Opportunistic infections
p24
p41
Viral load

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-818731-9.00184-1

Cite this

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title = "Human Immunodeficiency Virus (HIV)",

abstract = "HIV is the causative agent of AIDS. Binding of the virus to CD4 positive cells and a chemokine co-receptor initiate infection of myeloid and T cells. This results in a profound decrease in CD4 T cells, loss of cell mediated immune function and occurrence of opportunistic infections. Infection is diagnosed by sequential antibody or molecular assays and the viral infection is treated with multiple anti-retroviral drugs. The infection can be controlled but not eradicated as the virus continues to reside quiescent in the genetic material of a subset of target cells.",

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AU - Rosenthal, Ken S.

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AB - HIV is the causative agent of AIDS. Binding of the virus to CD4 positive cells and a chemokine co-receptor initiate infection of myeloid and T cells. This results in a profound decrease in CD4 T cells, loss of cell mediated immune function and occurrence of opportunistic infections. Infection is diagnosed by sequential antibody or molecular assays and the viral infection is treated with multiple anti-retroviral drugs. The infection can be controlled but not eradicated as the virus continues to reside quiescent in the genetic material of a subset of target cells.

KW - Acquired immunodeficiency syndrome (AIDS)

KW - Anti-retroviral treatment

KW - CD4

KW - gP120/160

KW - Human immunodeficiency virus (HIV)

KW - Opportunistic infections

KW - p24

KW - p41

KW - Viral load

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DO - 10.1016/B978-0-12-818731-9.00184-1

M3 - Chapter

AN - SCOPUS:85145841922

VL - 2

SP - 123

EP - 130

BT - Encyclopedia of Infection and Immunity

PB - Elsevier

ER -

Human Immunodeficiency Virus (HIV)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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