Human papillomavirus Type 2 DNA in oral verrucous carcinoma

K. Adler‐Storthz; J. R. Newland; B. A. Tessin; W. A. Yeudall; E. J. Shillitoe

doi:10.1111/j.1600-0714.1986.tb00661.x

Human papillomavirus Type 2 DNA in oral verrucous carcinoma

K. Adler‐Storthz, J. R. Newland, B. A. Tessin, W. A. Yeudall, E. J. Shillitoe

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (T_m‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (T_m‐20°), the virus in each case was identified as being HPV2.

Original language	English (US)
Pages (from-to)	472-475
Number of pages	4
Journal	Journal of Oral Pathology & Medicine
Volume	15
Issue number	9
DOIs	https://doi.org/10.1111/j.1600-0714.1986.tb00661.x
State	Published - Oct 1986
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oral Surgery
Otorhinolaryngology
Cancer Research
Periodontics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0714.1986.tb00661.x

Cite this

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title = "Human papillomavirus Type 2 DNA in oral verrucous carcinoma",

abstract = "Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.",

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year = "1986",

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language = "English (US)",

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T1 - Human papillomavirus Type 2 DNA in oral verrucous carcinoma

AU - Adler‐Storthz, K.

AU - Newland, J. R.

AU - Tessin, B. A.

AU - Yeudall, W. A.

AU - Shillitoe, E. J.

PY - 1986/10

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N2 - Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.

AB - Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). The tissues were stained for the presence of the type common papillomavirus antigen by immunohistochemical staining and the presence of HPV DNA was determined by in situ hybridization with biotin‐labelled HPV DNA probes. Seventeen tissue specimens were obtained from 9 patients, and included pre‐malignant lesions and primary and recurrent tumors. One pre‐malignant lesion was positive for papillomavirus structural antigen. This lesion and lesions from 2 other patients hybridized at low stringency (Tm‐35°) to 3 different HPV probes. By hybridization under high stringency conditions (Tm‐20°), the virus in each case was identified as being HPV2.

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Human papillomavirus Type 2 DNA in oral verrucous carcinoma

Abstract

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