Hyalinizing clear cell carcinoma of the head and neck: Case series and update

W. Greer Albergotti, Elizabeth A. Bilodeau, J. Kenneth Byrd, Mark M. Mims, Stella Lee, Seungwon Kim

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Background Hyalinizing clear cell carcinoma (HCCC) is a rare neoplasm of salivary gland origin which is low-grade in nature. In this series, we report on 9 cases of HCCC and update the literature. Methods A comprehensive literature search was performed. Our institutional database was queried for cases of HCCC. Pathology reports and slides were reviewed. Data was extracted, including demographics, staging, primary treatment, histopathologic findings, recurrence, and disease status. Statistical analysis was performed using a Pearson's chi-square test. Results One hundred thirty-six total cases were included for analysis. The overall recurrence rate was 19.8%. Necrosis was associated with risk of recurrence (p =.003). Positive margins and lymph node status were associated with risk of recurrence. Prognosis was good with only 3 of 82 patients reported dying with disease. Conclusion HCCC has an overall good prognosis with potential for aggressive behavior. The presence of necrosis, locoregional disease, or positive margins is associated with risk for recurrence.

Original languageEnglish (US)
Pages (from-to)426-433
Number of pages8
JournalHead and Neck
Issue number3
StatePublished - Mar 1 2016
Externally publishedYes


  • EWSR1
  • clear cell carcinoma
  • head and neck cancer
  • hyalinizing clear cell carcinoma
  • salivary gland cancer

ASJC Scopus subject areas

  • Otorhinolaryngology


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