Hyalurondiase: Both a tumor promoter and suppressor

Vinata B. Lokeshwar, Marie G. Selzer

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


Originally termed as the "spreading factor", hyaluronidases (HAases) are present in a variety of toxins and venoms. For example, HAase is the virulent factor of β-hemolytic Streptococci and it is also present in the venoms of snake, bee, wasp, scorpion, etc, where it aids in the spread of these venoms in the body. In mammals, testicular HAase present in the sperm acrosome is necessary for the fertilization of the ovum. Despite a lot of work on bacterial, invertebrate and testicular HAases, a connection between HAase and cancer was unequivocally established just over a decade ago and the functional significance of HAases in cancer was demonstrated just about a year ago. In this part of the review, we will focus on the recent advances in our understanding of the role of HAases in cancer.

Original languageEnglish (US)
Pages (from-to)281-287
Number of pages7
JournalSeminars in Cancer Biology
Issue number4
StatePublished - Aug 2008
Externally publishedYes


  • Angiogenesis
  • Cancer diagnosis
  • Cancer prognosis
  • Hyaluronic acid
  • Hyaluronidase
  • Infiltration
  • Tumor growth
  • Tumor promoter
  • Tumor suppressor

ASJC Scopus subject areas

  • Cancer Research


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