Hydroxyurea adherence strategies for persons with sickle cell disease: A systematic review

Lori Vick, Maryellen Potts, Megan Jaskowiak, Robert W. Gibson

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Introduction. Adherence to hydroxyurea is essential to modify the pathology of sickle cell disease. Objective. To identify best strategies to support adherence to hydroxyurea in persons with sickle cell disease. Methods. A systematic review was conducted. PubMed, Cumulative Index of Nursing and Allied Health Literature, PsycArticles, PsycInfo, Embase databases and Cochrane Library were searched for studies between 1998 to 2018. Results. Six studies met inclusion criteria: two randomized controlled trials, three prospective studies, and one retrospective chart review. Discussion. Few studies addressed strategies that tested adherence interventions primarily composed of behavioral change resulting in medication adherence. More studies on hydroxyurea adherence are needed.

Original languageEnglish (US)
Pages (from-to)99-118
Number of pages20
JournalJournal of Health Care for the Poor and Underserved
Issue number1
StatePublished - 2021


  • Adherence
  • Hydroxyurea
  • Medication
  • Sickle cell

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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