Hyperprothrombinemia as a result of a possible warfarin and intravaginal miconazole interaction

Jeremy L. Thomas; Donald Dunn; Allen L. Pelletier; Andrea S. Franks

doi:10.1097/SMJ.0b013e3181ebee0e

Hyperprothrombinemia as a result of a possible warfarin and intravaginal miconazole interaction

Jeremy L. Thomas, Donald Dunn, Allen L. Pelletier, Andrea S. Franks

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Warfarin, a commonly prescribed anticoagulant, has many potential drug interactions. We describe a case of intravaginal miconazole potentiating the effects of warfarin in a patient previously stable on a consistent dose of 8.5 mg warfarin daily. Following a course of intravaginal miconazole and a dosage increase to 9 mg daily, her international normalized ratio (INR) increased from 2.0 to 5. After the course of miconazole was complete, the patient was stable with a therapeutic INR (mean INR 2.9) on 9 mg warfarin daily. Clinicians should consider the possibility of systemic absorption of intravaginal miconazole, and a resultant increase in warfarin's anticoagulant effect.

Original language	English (US)
Pages (from-to)	1063-1065
Number of pages	3
Journal	Southern Medical Journal
Volume	103
Issue number	10
DOIs	https://doi.org/10.1097/SMJ.0b013e3181ebee0e
State	Published - Oct 1 2010
Externally published	Yes

Keywords

Aticoagulation
Drug interaction
Mconazole
Wrfarin

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1097/SMJ.0b013e3181ebee0e

Cite this

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title = "Hyperprothrombinemia as a result of a possible warfarin and intravaginal miconazole interaction",

abstract = "Warfarin, a commonly prescribed anticoagulant, has many potential drug interactions. We describe a case of intravaginal miconazole potentiating the effects of warfarin in a patient previously stable on a consistent dose of 8.5 mg warfarin daily. Following a course of intravaginal miconazole and a dosage increase to 9 mg daily, her international normalized ratio (INR) increased from 2.0 to 5. After the course of miconazole was complete, the patient was stable with a therapeutic INR (mean INR 2.9) on 9 mg warfarin daily. Clinicians should consider the possibility of systemic absorption of intravaginal miconazole, and a resultant increase in warfarin's anticoagulant effect.",

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AU - Thomas, Jeremy L.

AU - Dunn, Donald

AU - Pelletier, Allen L.

AU - Franks, Andrea S.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Warfarin, a commonly prescribed anticoagulant, has many potential drug interactions. We describe a case of intravaginal miconazole potentiating the effects of warfarin in a patient previously stable on a consistent dose of 8.5 mg warfarin daily. Following a course of intravaginal miconazole and a dosage increase to 9 mg daily, her international normalized ratio (INR) increased from 2.0 to 5. After the course of miconazole was complete, the patient was stable with a therapeutic INR (mean INR 2.9) on 9 mg warfarin daily. Clinicians should consider the possibility of systemic absorption of intravaginal miconazole, and a resultant increase in warfarin's anticoagulant effect.

AB - Warfarin, a commonly prescribed anticoagulant, has many potential drug interactions. We describe a case of intravaginal miconazole potentiating the effects of warfarin in a patient previously stable on a consistent dose of 8.5 mg warfarin daily. Following a course of intravaginal miconazole and a dosage increase to 9 mg daily, her international normalized ratio (INR) increased from 2.0 to 5. After the course of miconazole was complete, the patient was stable with a therapeutic INR (mean INR 2.9) on 9 mg warfarin daily. Clinicians should consider the possibility of systemic absorption of intravaginal miconazole, and a resultant increase in warfarin's anticoagulant effect.

KW - Aticoagulation

KW - Drug interaction

KW - Mconazole

KW - Wrfarin

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Hyperprothrombinemia as a result of a possible warfarin and intravaginal miconazole interaction

Abstract

Keywords

ASJC Scopus subject areas

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