TY - JOUR
T1 - Hypertension induced morphological and physiological changes in cells of the arterial wall
AU - Martinez-Quinones, Patricia
AU - McCarthy, Cameron G.
AU - Watts, Stephanie W.
AU - Klee, Nicole S.
AU - Komic, Amel
AU - Calmasini, Fabiano B.
AU - Priviero, Fernanda
AU - Warner, Alexander
AU - Chenghao, Yu
AU - Wenceslau, Camilla F.
N1 - Publisher Copyright:
© American Journal of Hypertension, Ltd 2018. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PY - 2018/9/11
Y1 - 2018/9/11
N2 - Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.
AB - Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.
KW - blood pressure; cell types
KW - hypertension
KW - vascular
KW - vessel wall
UR - http://www.scopus.com/inward/record.url?scp=85053816556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053816556&partnerID=8YFLogxK
U2 - 10.1093/ajh/hpy083
DO - 10.1093/ajh/hpy083
M3 - Review article
C2 - 29788246
AN - SCOPUS:85053816556
SN - 0895-7061
VL - 31
SP - 1067
EP - 1078
JO - American journal of hypertension
JF - American journal of hypertension
IS - 10
ER -