Identification of the Time-Dependent Proliferation Coefficient for a Brain Tumor Model

He Yang, Justice Howley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we consider an inverse problem that arises in a brain tumor model. The reaction-diffusion model is used to describe the time evolution for the net rate of growth of glioma cells, one of the most common types of brain tumor. The inverse problem is to reconstruct the concentration of glioma cells and the proliferation coefficient based on some given data. Under certain consistency conditions for the data, we prove the existence and uniqueness of the inverse problem. When further assumptions are made, we can show the stability of the inverse problem. We also develop a numerical method to solve the inverse problem and demonstrate its performance using three numerical examples.

Original languageEnglish (US)
Title of host publicationApplied Mathematical Analysis and Computations II - 1st SGMC
EditorsDivine Wanduku, Shijun Zheng, Zhan Chen, Andrew Sills, Haomin Zhou, Ephraim Agyingi
PublisherSpringer
Pages21-45
Number of pages25
ISBN (Print)9783031697098
DOIs
StatePublished - 2024
Event1st Southern Georgia Mathematics Conference, SGMC 2021 - Virtual, Online
Duration: Apr 2 2021Apr 3 2021

Publication series

NameSpringer Proceedings in Mathematics and Statistics
Volume472
ISSN (Print)2194-1009
ISSN (Electronic)2194-1017

Conference

Conference1st Southern Georgia Mathematics Conference, SGMC 2021
CityVirtual, Online
Period4/2/214/3/21

Keywords

  • Brain tumor model
  • Inverse problem
  • Reaction-diffusion equation

ASJC Scopus subject areas

  • General Mathematics

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