IL4 and IL4Rα genes are not linked or associated with type 1 diabetes

Sharon K. Reimsnider, Sarah E. Eckenrode, Michele P. Marron, Andrew Muir, Jin Xiong She

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Previous studies have shown the immunoregulatory functions IL-4 in type 1 diabetes mellitus. Therefore, the genes involved in the IL-4 regulatory pathway are candidates for diabetes susceptibility genes. Here we have evaluated IL4 and the alpha subunit of the IL-4 receptor (IL4Rα) genes using the affected sibpair (ASP) and transmission/disequilibrium test (TDT). We analyzed 309 diabetic families from the United States and 87 families from various European countries. There was no evidence that either of these two genes are linked or associated with type 1 diabetes. Means by which IL-4 directed signals could indirectly alter diabetes susceptibility are proposed.

Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
JournalPediatric research
Issue number2
StatePublished - Feb 2000
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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