Immune response in hosts with cadaveric dural grafts. Report of two cases

Cargill Herley Alleyne, D. L. Barrow

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The use of cadaveric human dura has been critical in the repair of dural defects since the dawn of neurosurgery. Reports in the literature of immune response to this type of graft have been extremely rare. Two patients are presented who received cadaveric dural implants with resulting meningeal signs and cerebrospinal fluid eosinophilia several weeks after surgery. Peripheral eosinophilia was present in one patient. The signs and symptoms resolved temporarily during corticosteroid therapy and permanently upon removal of the offending grafts. These cases illustrate that an immune-type reaction can occur with significant morbidity in patients receiving cadaveric dural grafts. A proposed mechanism for this response is discussed.

Original languageEnglish (US)
Pages (from-to)610-613
Number of pages4
JournalJournal of Neurosurgery
Issue number4
StatePublished - Jan 1 1994


  • dura mater
  • dural graft
  • immune response

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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