Abstract
There is now overwhelming experimental and clinical evidence that arteriosclerosis is a chronic inflammatory disease. Lessons learned from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice models and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb arteriosclerosis. This article summarizes and discusses the pathogenesis of arteriosclerosis with a focus on the role of the adaptive immune system. Some limitations of animal models are discussed and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment are emphasized.
Translated title of the contribution | Immunity and inflammation in atherosclerosis |
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Original language | German |
Pages (from-to) | 107-120 |
Number of pages | 14 |
Journal | Herz |
Volume | 44 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 2019 |
Externally published | Yes |
Keywords
- Animal models
- Blood vessels
- Immune system
- Lymphocytes
- Vaccination
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine