Abstract
There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
Original language | English (US) |
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Pages (from-to) | 315-327 |
Number of pages | 13 |
Journal | Circulation research |
Volume | 124 |
Issue number | 2 |
DOIs | |
State | Published - Jan 18 2019 |
Externally published | Yes |
Keywords
- adaptive immunity
- atherosclerosis
- immunity
- inflammation
- myeloid cells
- vaccination
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine