Immunocytochemical study of ras and myc proto-oncogene polypeptide expression in the human menstrual cycle

Lawrence D. Odom, J. Michael Barrett, Cooley G. Pantazis, Leland D. Stoddard, Paul G. McDonough

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The human endometrium is a unique and dynamic tissue model system characterized by cyclic processes of cellular proliferation, differentiation, and menstrual desquamation. Both the glandular epithelial and stromal mesenchymal components work in synchronous response to the mitogenetic effect of estradiol and the antimitogenetic effect of progesterone. Mechanisms whereby estradiol and progesterone exert their effects are not completely understood. This study was undertaken to evaluate the expression and localization of the polypeptide products of the ras and myc proto-oncogenes sequentially during the menstrual cycle. Sixteen endometrial biopsy specimens were evaluated. Immunocytochemical quantitation of ras and myc expression was done by use of color image analysis (CoreScan). There was no cyclic variation in the ras polypeptide product, but the expression of myc polypeptide was low in the secretory phase and high in the proliferative phase.

Original languageEnglish (US)
Pages (from-to)1663-1668
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Issue number6 PART 1
StatePublished - Dec 1989


  • Proto-oncogene
  • endometrium
  • menstrual cycle
  • myc
  • ras

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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