Immunologic Reactions of Lepromatous Leprosy

Thomas R. Swift, Byron H. Waksman

Research output: Contribution to journalLetterpeer-review


To the Editor: In his recent editorial, Waksman (N Engl J Med 286:431–432, 1972), in discussing measurement of cell-mediated immunity (CMI), makes reference to dysfunction of the CMI system as being responsible for reaction in lepromatous leprosy (known as erythema nodosum leprosum or ENL). Although patients with lepromatous leprosy have defective CMI,14 which may be one factor responsible for the development of lepromatous disease in the first place,5 the specific immunologic reaction referred to in the editorial is mediated by the humoral antibody system. Antibody reacts with excess mycobacterial antigen from dead bacilli. In a zone of “excess antigen” these.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number16
StatePublished - Apr 20 1972
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Immunologic Reactions of Lepromatous Leprosy'. Together they form a unique fingerprint.

Cite this