Abstract
Mammalian reproduction poses an immunological paradox because fetal alloantigens encoded by genes inherited from the father should provoke responses by maternal T cells leading to fetal loss. Current understanding of T cell immunobiology and the critical role of inflammatory processes during pregnancy is reviewed and discussed. Lessons derived from studies on the regulation of T cell responsiveness during mammalian gestation are considered in the wider context of T cell tolerance toward some microbial infections and tumors, avoidance of autoimmunity, and tissue allograft rejection.
Original language | English (US) |
---|---|
Pages (from-to) | 367-391 |
Number of pages | 25 |
Journal | Annual Review of Immunology |
Volume | 18 |
DOIs | |
State | Published - 2000 |
Keywords
- Inflammation
- Macrophages
- Placenta
- Pregnancy
- T cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology