TY - JOUR
T1 - Impact of Human Immunodeficiency Virus Infection on Survival and Acute Toxicities From Chemoradiation Therapy for Cervical Cancer Patients in a Limited-Resource Setting
AU - Grover, Surbhi
AU - Bvochora-Nsingo, Memory
AU - Yeager, Alyssa
AU - Chiyapo, Sebathu
AU - Bhatia, Rohini
AU - MacDuffie, Emily
AU - Puri, Priya
AU - Balang, Dawn
AU - Ratcliffe, Sarah
AU - Narasimhamurthy, Mohan
AU - Gwangwava, Elliphine
AU - Tsietso, Sylvia
AU - Kayembe, Mukendi K.A.
AU - Ramogola-Masire, Doreen
AU - Dryden-Peterson, Scott
AU - Mahantshetty, Umesh
AU - Viswanathan, Akila N.
AU - Zetola, Nicola M.
AU - Lin, Lilie L.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Purpose: To prospectively compare survival between human immunodeficiency virus (HIV)-infected versus HIV-uninfected cervical cancer patients who initiated curative chemoradiation therapy (CRT) in a limited-resource setting. Methods and Materials: Women with locally advanced cervical cancer with or without HIV infection initiating radical CRT in Botswana were enrolled in a prospective, observational, cohort study from July 2013 through January 2015. Results: Of 182 women treated for cervical cancer during the study period, 143 women initiating curative CRT were included in the study. Eighty-five percent of the participants (122 of 143) had stage II/III cervical cancer, and 67% (96 of 143) were HIV-infected. All HIV-infected patients were receiving antiretroviral therapy (ART) at the time of curative cervical cancer treatment initiation. We found no difference in toxicities between HIV-infected and HIV-uninfected women. The 2-year overall survival (OS) rates were 65% for HIV-infected women (95% confidence interval [CI] 54%-74%) and 66% for HIV-uninfected women (95% CI 49%-79%) (P =.70). Factors associated with better 2-year OS on multivariate analyses included baseline hemoglobin >10 g/dL (hazard ratio [HR] 0.37, 95% CI 0.19-0.72, P =.003), total radiation dose ≥75 Gy (HR 0.52, 95% CI 0.27-0.97, P =.04), and age <40 years versus 40-59 years (HR 2.17, 95% CI 1.05-4.47, P =.03). Conclusions: Human immunodeficiency virus status had no effect on 2-year OS or on acute toxicities in women with well-managed HIV infection who initiated curative CRT in Botswana. In our cohort, we found that baseline hemoglobin levels, total radiation dose, and age were associated with survival, regardless of HIV status.
AB - Purpose: To prospectively compare survival between human immunodeficiency virus (HIV)-infected versus HIV-uninfected cervical cancer patients who initiated curative chemoradiation therapy (CRT) in a limited-resource setting. Methods and Materials: Women with locally advanced cervical cancer with or without HIV infection initiating radical CRT in Botswana were enrolled in a prospective, observational, cohort study from July 2013 through January 2015. Results: Of 182 women treated for cervical cancer during the study period, 143 women initiating curative CRT were included in the study. Eighty-five percent of the participants (122 of 143) had stage II/III cervical cancer, and 67% (96 of 143) were HIV-infected. All HIV-infected patients were receiving antiretroviral therapy (ART) at the time of curative cervical cancer treatment initiation. We found no difference in toxicities between HIV-infected and HIV-uninfected women. The 2-year overall survival (OS) rates were 65% for HIV-infected women (95% confidence interval [CI] 54%-74%) and 66% for HIV-uninfected women (95% CI 49%-79%) (P =.70). Factors associated with better 2-year OS on multivariate analyses included baseline hemoglobin >10 g/dL (hazard ratio [HR] 0.37, 95% CI 0.19-0.72, P =.003), total radiation dose ≥75 Gy (HR 0.52, 95% CI 0.27-0.97, P =.04), and age <40 years versus 40-59 years (HR 2.17, 95% CI 1.05-4.47, P =.03). Conclusions: Human immunodeficiency virus status had no effect on 2-year OS or on acute toxicities in women with well-managed HIV infection who initiated curative CRT in Botswana. In our cohort, we found that baseline hemoglobin levels, total radiation dose, and age were associated with survival, regardless of HIV status.
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U2 - 10.1016/j.ijrobp.2018.01.067
DO - 10.1016/j.ijrobp.2018.01.067
M3 - Article
C2 - 29619965
AN - SCOPUS:85044569603
SN - 0360-3016
VL - 101
SP - 201
EP - 210
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 1
ER -