TY - JOUR
T1 - Impact of metabolic diseases on cerebral circulation
T2 - Structural and functional consequences
AU - Coucha, Maha
AU - Abdelsaid, Mohammed
AU - Ward, Rebecca
AU - Abdul, Yasir
AU - Ergul, Adviye
N1 - Funding Information:
AE is a Research Career Scientist at the Charlie Norwood Veterans Affairs Medical Center in Augusta, Georgia. This work was supported in part by a Veterans Affairs (VA) Merit Award (BX000347), VAResearch Career ScientistAward and National Institutes of Health (NIH) awards (R01NS083559, PO1HL128207) to AE and Scientist Development Grant (16SDG30270013) to MA. The contents do not represent the views of the Department of Veterans Affairs or the US Government. Authors would like to thank Ms LaDonya Jackson for editing the manuscript.
Publisher Copyright:
© 2018 American Physiological Society.
PY - 2018/4
Y1 - 2018/4
N2 - Metabolic diseases including obesity, insulin resistance, and diabetes have profound effects on cerebral circulation. These diseases not only affect the architecture of cerebral blood arteries causing adverse remodeling, pathological neovascularization, and vasoregression but also alter the physiology of blood vessels resulting in compromised myogenic reactivity, neurovascular uncoupling, and endothelial dysfunction. Coupled with the disruption of blood brain barrier (BBB) integrity, changes in blood flow and microbleeds into the brain rapidly occur. This overview is organized into sections describing cerebrovascular architecture, physiology, and BBB in these diseases. In each section, we review these properties starting with larger arteries moving into smaller vessels. Where information is available, we review in the order of obesity, insulin resistance, and diabetes. We also tried to include information on biological variables such as the sex of the animal models noted since most of the information summarized was obtained using male animals.
AB - Metabolic diseases including obesity, insulin resistance, and diabetes have profound effects on cerebral circulation. These diseases not only affect the architecture of cerebral blood arteries causing adverse remodeling, pathological neovascularization, and vasoregression but also alter the physiology of blood vessels resulting in compromised myogenic reactivity, neurovascular uncoupling, and endothelial dysfunction. Coupled with the disruption of blood brain barrier (BBB) integrity, changes in blood flow and microbleeds into the brain rapidly occur. This overview is organized into sections describing cerebrovascular architecture, physiology, and BBB in these diseases. In each section, we review these properties starting with larger arteries moving into smaller vessels. Where information is available, we review in the order of obesity, insulin resistance, and diabetes. We also tried to include information on biological variables such as the sex of the animal models noted since most of the information summarized was obtained using male animals.
UR - http://www.scopus.com/inward/record.url?scp=85045007290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045007290&partnerID=8YFLogxK
U2 - 10.1002/cphy.c170019
DO - 10.1002/cphy.c170019
M3 - Article
AN - SCOPUS:85045007290
SN - 2040-4603
VL - 8
SP - 773
EP - 799
JO - Comprehensive Physiology
JF - Comprehensive Physiology
IS - 2
ER -