In situ monitoring of biomolecular processes in living systems using surface-enhanced Raman scattering

Mine Altunbek, Seda Kelestemur, Mustafa Culha

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Surface-enhanced Raman scattering (SERS) continues to strive to gather molecular level information from dynamic biological systems. It is our ongoing effort to utilize the technique for understanding of the biomolecular processes in living systems such as eukaryotic and prokaryotic cells. In this study, the technique is investigated to identify cell death mechanisms in 2D and 3D in vitro cell culture models, which is a very important process in tissue engineering and pharmaceutical applications. Second, in situ biofilm formation monitoring is investigated to understand how microorganisms respond to the environmental stimuli, which inferred information can be used to interfere with biofilm formation and fight against their pathogenic activity.

Original languageEnglish (US)
Title of host publicationBiophotonics Japan 2015
EditorsTakashige Omatsu, Yasuyuki Ozeki, Seigo Ohno, Yoshio Hayasaki, Yusuke Ogura
ISBN (Electronic)9781510600270
StatePublished - 2015
Externally publishedYes
EventBiophotonics Japan 2015 - Tokyo, Japan
Duration: Oct 27 2015Oct 28 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceBiophotonics Japan 2015


  • apoptosis
  • biofilm
  • Cell death
  • microorganisms
  • necrosis
  • SERS

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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