In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin

John C H Steele; Barbara H. Edwards; John Peter Rissing

doi:10.1093/jac/16.4.463

In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin

John C H Steele
, Barbara H. Edwards
, John Peter Rissing

Division of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC₉₀) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC₉₀=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC₉₀=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8->32 mg/l).

Original language	English (US)
Pages (from-to)	463-468
Number of pages	6
Journal	Journal of Antimicrobial Chemotherapy
Volume	16
Issue number	4
DOIs	https://doi.org/10.1093/jac/16.4.463
State	Published - Oct 1985

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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title = "In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin",

abstract = "The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90\% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8->32 mg/l).",

author = "Steele, \{John C H\} and Edwards, \{Barbara H.\} and Rissing, \{John Peter\}",

year = "1985",

month = oct,

doi = "10.1093/jac/16.4.463",

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AU - Steele, John C H

AU - Edwards, Barbara H.

AU - Rissing, John Peter

PY - 1985/10

Y1 - 1985/10

N2 - The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8->32 mg/l).

AB - The in-vitro activity of BMY 28142, a new α-methoxyimino aminothiazolyl cephalosporin, was determined by microdilution broth techniques. The agent demonstrated excellent activity against recent clinical Enterobacteriaceae isolates with a 90% minimum inhibitory concentration (MIC90) of 0·25 mg/l or less for all but one species tested. BMY 28142 inhibited all Pseudomonas aeruginosa strains tested (MIC90=8·0 mg/l) as well as most other non-fermentative bacteria studied. Methicillin-susceptible Staphylococcus aureus were susceptible to BMY 28142 with MIC90=4·0 mg/l, while methicillin-resistant strains were generally resistant (MIC range 8->32 mg/l).

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ER -

In-vitro activity of BMY 28142, a new aminothiazolyl cephalosporin

Abstract

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