In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi

J. S. De Araújo; C. F. Da Silva; D. G.J. Batista; P. B. Da Silva; M. B. Meuser; C. A.F. Aiub; M. F.V. Da Silva; C. F. Araújo-Lima; M. Banerjee; A. A. Farahat; C. E. Stephens; A. Kumar; D. W. Boykin; M. N.C. Soeiro

doi:10.1128/AAC.01403-13

In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi

J. S. De Araújo, C. F. Da Silva, D. G.J. Batista, P. B. Da Silva, M. B. Meuser, C. A.F. Aiub, M. F.V. Da Silva, C. F. Araújo-Lima, M. Banerjee, A. A. Farahat, C. E. Stephens, A. Kumar, D. W. Boykin, M. N.C. Soeiro

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.

Original language	English (US)
Pages (from-to)	4191-4195
Number of pages	5
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	7
DOIs	https://doi.org/10.1128/AAC.01403-13
State	Published - Jul 2014

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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De Araújo, J. S., Da Silva, C. F., Batista, D. G. J., Da Silva, P. B., Meuser, M. B., Aiub, C. A. F., Da Silva, M. F. V., Araújo-Lima, C. F., Banerjee, M., Farahat, A. A., Stephens, C. E., Kumar, A., Boykin, D. W., & Soeiro, M. N. C. (2014). In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi. Antimicrobial agents and chemotherapy, 58(7), 4191-4195. https://doi.org/10.1128/AAC.01403-13

De Araújo, JS, Da Silva, CF, Batista, DGJ, Da Silva, PB, Meuser, MB, Aiub, CAF, Da Silva, MFV, Araújo-Lima, CF, Banerjee, M, Farahat, AA, Stephens, CE, Kumar, A, Boykin, DW & Soeiro, MNC 2014, 'In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi', Antimicrobial agents and chemotherapy, vol. 58, no. 7, pp. 4191-4195. https://doi.org/10.1128/AAC.01403-13

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abstract = "Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.",

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AU - Batista, D. G.J.

AU - Da Silva, P. B.

AU - Meuser, M. B.

AU - Aiub, C. A.F.

AU - Da Silva, M. F.V.

AU - Araújo-Lima, C. F.

AU - Banerjee, M.

AU - Farahat, A. A.

AU - Stephens, C. E.

AU - Kumar, A.

AU - Boykin, D. W.

AU - Soeiro, M. N.C.

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In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi

Abstract

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