In vivo microdialysis study on changes in septal dynorphin and β-endorphin activities in active and hibernating Columbian ground squirrels

Y. Cui; T. F. Lee; L. C.H. Wang

doi:10.1016/0006-8993(95)01528-0

In vivo microdialysis study on changes in septal dynorphin and β-endorphin activities in active and hibernating Columbian ground squirrels

Y. Cui, T. F. Lee, L. C.H. Wang

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

State-dependent changes in extracellular concentration of endogenous opioids in the septum of Columbian ground squirrels were examined in the hibernating and euthermic states using in vivo microdialysis. The order of estimated extracellular concentration was found to be: hibernating > interbout euthermia > non-hibernating euthermia for dynorphin A and interbout euthermia > hibernating > non-hibernating euthermia for β-endorphin. The apparent turnover rates of dynorphin A during hibernation was 15 times greater than that during euthermic non-hibernation phase and that of β-endorphin was 8-fold greater. These results demonstrate that subfamilies of endogenous opioids may vary differentially in their activities at different stages of an annual hibernation cycle and may reflect their different roles in the regulation of hibernation.

Original language	English (US)
Pages (from-to)	271-274
Number of pages	4
Journal	Brain Research
Volume	710
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(95)01528-0
State	Published - Feb 26 1996
Externally published	Yes

Keywords

Dynorphin A
Hibernation
Opioid
Septum
β-Endorphin

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(95)01528-0

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title = "In vivo microdialysis study on changes in septal dynorphin and β-endorphin activities in active and hibernating Columbian ground squirrels",

abstract = "State-dependent changes in extracellular concentration of endogenous opioids in the septum of Columbian ground squirrels were examined in the hibernating and euthermic states using in vivo microdialysis. The order of estimated extracellular concentration was found to be: hibernating > interbout euthermia > non-hibernating euthermia for dynorphin A and interbout euthermia > hibernating > non-hibernating euthermia for β-endorphin. The apparent turnover rates of dynorphin A during hibernation was 15 times greater than that during euthermic non-hibernation phase and that of β-endorphin was 8-fold greater. These results demonstrate that subfamilies of endogenous opioids may vary differentially in their activities at different stages of an annual hibernation cycle and may reflect their different roles in the regulation of hibernation.",

keywords = "Dynorphin A, Hibernation, Opioid, Septum, β-Endorphin",

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year = "1996",

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language = "English (US)",

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T1 - In vivo microdialysis study on changes in septal dynorphin and β-endorphin activities in active and hibernating Columbian ground squirrels

AU - Cui, Y.

AU - Lee, T. F.

AU - Wang, L. C.H.

PY - 1996/2/26

Y1 - 1996/2/26

N2 - State-dependent changes in extracellular concentration of endogenous opioids in the septum of Columbian ground squirrels were examined in the hibernating and euthermic states using in vivo microdialysis. The order of estimated extracellular concentration was found to be: hibernating > interbout euthermia > non-hibernating euthermia for dynorphin A and interbout euthermia > hibernating > non-hibernating euthermia for β-endorphin. The apparent turnover rates of dynorphin A during hibernation was 15 times greater than that during euthermic non-hibernation phase and that of β-endorphin was 8-fold greater. These results demonstrate that subfamilies of endogenous opioids may vary differentially in their activities at different stages of an annual hibernation cycle and may reflect their different roles in the regulation of hibernation.

AB - State-dependent changes in extracellular concentration of endogenous opioids in the septum of Columbian ground squirrels were examined in the hibernating and euthermic states using in vivo microdialysis. The order of estimated extracellular concentration was found to be: hibernating > interbout euthermia > non-hibernating euthermia for dynorphin A and interbout euthermia > hibernating > non-hibernating euthermia for β-endorphin. The apparent turnover rates of dynorphin A during hibernation was 15 times greater than that during euthermic non-hibernation phase and that of β-endorphin was 8-fold greater. These results demonstrate that subfamilies of endogenous opioids may vary differentially in their activities at different stages of an annual hibernation cycle and may reflect their different roles in the regulation of hibernation.

KW - Dynorphin A

KW - Hibernation

KW - Opioid

KW - Septum

KW - β-Endorphin

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DO - 10.1016/0006-8993(95)01528-0

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SN - 0006-8993

VL - 710

SP - 271

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JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

In vivo microdialysis study on changes in septal dynorphin and β-endorphin activities in active and hibernating Columbian ground squirrels

Abstract

Keywords

ASJC Scopus subject areas

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