Inactivation of Class A β-Lactamases by Clavulanic Acid: The Role of Arginine-244 in a Proposed Nonconcerted Sequence of Events

Engineering & Materials Science

• Acids 51%
• Acylation 27%
• Amines 33%
• Anchors 28%
• Arginine 99%
• Bacilli 20%
• Binding sites 19%
• Crystal structure 18%
• Deprotonation 85%
• Electrostatics 15%
• Enzyme kinetics 22%
• Enzymes 65%
• Escherichia coli 18%
• Hydrogen bonds 19%
• Molecular dynamics 15%
• Molecules 13%
• Nucleophiles 29%
• Protons 17%
• Substrates 9%
• Transmission electron microscopy 29%
• Water 15%

Chemical Compounds

• Acylation 6%
• Amine 9%
• Ampicillin 8%
• Chemistry 8%
• Clavulanate 100%
• Clavulanic Acid 85%
• Crystal Structure 3%
• Deprotonation 19%
• Enamine 7%
• Molecular Dynamics 5%
• Molecule 2%
• Mutation 6%
• Nucleophile 6%
• Oxazolidine 10%
• Proton 4%
• Resistance 4%
• Strain 4%
• Transition State 5%

Medicine & Life Sciences

• Acylation 8%
• Amines 13%
• Ampicillin Resistance 8%
• Arginine 52%
• Bacillus licheniformis 9%
• Catalytic Domain 5%
• Clavulanic Acid 73%
• Enzymes 13%
• Escherichia coli 4%
• Hydrogen Bonding 7%
• Hydroxyl Radical 13%
• Kinetics 4%
• Molecular Computers 10%
• Molecular Dynamics Simulation 7%
• Mutation 3%
• oxazolidine 12%
• Protons 6%
• Static Electricity 7%
• Water 8%