TY - JOUR
T1 - Incidence of sudden cardiac death associated with hypertension and left ventricular hypertrophy is reduced by chronic β-adrenergic blockade
AU - Dellsperger, Kevin C
AU - Martins, J. B.
AU - Clothier, J. L.
AU - Marcus, M. L.
PY - 1990
Y1 - 1990
N2 - Because β-adrenergic blockade has as one of its many effects altered electrophysiological abnormalities after dogs with left ventricular hypertrophy have been subjected to coronary occlusion, we tested the hypothesis that metoprolol (200-400 mg/day) would reduce mortality rates in dogs with one-kidney, one clip left ventricular hypertrophy while a similar reduction in arterial pressure with enalapril (20-40 mg/day) would not. Dogs with left ventricular hypertrophy were given metoprolol or enalapril for 5-7 days before a 3-hour coronary occlusion. Infarct size and risk area were measured with triphenyltetrazolium chloride stain and barium angiography, respectively. For control (n = 15), left ventricular hypertrophy (n =17), left ventricular hypertrophy plus metoprolol (n = 12), and left ventricular hypertrophy plus enalapril (n = 15) groups, mean arterial pressure, ratio of infarct size to risk area, and dogs experiencing sudden death were 110 ± 4, 142 ± 4, 121 ± 7, and 120 ± 3 mm Hg; 44 ± 5%, 65 ± 5%, 44% ± 7%, and 30 ± 4%; and 27%, 65%, 17%, and 53%, respectively. Thus, the excessive increase in early mortality occurring when dogs with hypertension and left ventricular hypertrophy undergo coronary occlusion is interrupted with β-blockade, possibly via electrophysiological effects rather than by changes in arterial pressure or infarct size.
AB - Because β-adrenergic blockade has as one of its many effects altered electrophysiological abnormalities after dogs with left ventricular hypertrophy have been subjected to coronary occlusion, we tested the hypothesis that metoprolol (200-400 mg/day) would reduce mortality rates in dogs with one-kidney, one clip left ventricular hypertrophy while a similar reduction in arterial pressure with enalapril (20-40 mg/day) would not. Dogs with left ventricular hypertrophy were given metoprolol or enalapril for 5-7 days before a 3-hour coronary occlusion. Infarct size and risk area were measured with triphenyltetrazolium chloride stain and barium angiography, respectively. For control (n = 15), left ventricular hypertrophy (n =17), left ventricular hypertrophy plus metoprolol (n = 12), and left ventricular hypertrophy plus enalapril (n = 15) groups, mean arterial pressure, ratio of infarct size to risk area, and dogs experiencing sudden death were 110 ± 4, 142 ± 4, 121 ± 7, and 120 ± 3 mm Hg; 44 ± 5%, 65 ± 5%, 44% ± 7%, and 30 ± 4%; and 27%, 65%, 17%, and 53%, respectively. Thus, the excessive increase in early mortality occurring when dogs with hypertension and left ventricular hypertrophy undergo coronary occlusion is interrupted with β-blockade, possibly via electrophysiological effects rather than by changes in arterial pressure or infarct size.
KW - Enalapril
KW - Hypertension
KW - Left ventricular hypertrophy
KW - Metroprolol
KW - Occlusions
KW - β-adrenergic blockers
UR - http://www.scopus.com/inward/record.url?scp=0025111363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025111363&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.82.3.941
DO - 10.1161/01.CIR.82.3.941
M3 - Article
C2 - 1975521
AN - SCOPUS:0025111363
SN - 0009-7322
VL - 82
SP - 941
EP - 950
JO - Circulation
JF - Circulation
IS - 3
ER -