Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice

G. Faulds; S. Conroy; M. Madaio; D. Isenberg; D. Latchman

doi:10.1093/rheumatology/34.7.610

Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice

G. Faulds, S. Conroy, M. Madaio, D. Isenberg, D. Latchman

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.

Original language	English (US)
Pages (from-to)	610-615
Number of pages	6
Journal	Rheumatology
Volume	34
Issue number	7
DOIs	https://doi.org/10.1093/rheumatology/34.7.610
State	Published - Jul 1995
Externally published	Yes

Keywords

Autoantibodies
Heat shock proteins
Mrl/lpr mouse
SLE

ASJC Scopus subject areas

Rheumatology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/rheumatology/34.7.610

Cite this

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title = "Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice",

abstract = "Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.",

keywords = "Autoantibodies, Heat shock proteins, Mrl/lpr mouse, SLE",

author = "G. Faulds and S. Conroy and M. Madaio and D. Isenberg and D. Latchman",

note = "Funding Information: We would like to thank Paul Levy for technical assistance with the mice and all the collaborators mentioned in the text. GBF is supported by an Arthritis and Rheumatism Council prize studentship. SEC is supported by an MRC studentship.",

year = "1995",

month = jul,

doi = "10.1093/rheumatology/34.7.610",

language = "English (US)",

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T1 - Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice

AU - Faulds, G.

AU - Conroy, S.

AU - Madaio, M.

AU - Isenberg, D.

AU - Latchman, D.

N1 - Funding Information: We would like to thank Paul Levy for technical assistance with the mice and all the collaborators mentioned in the text. GBF is supported by an Arthritis and Rheumatism Council prize studentship. SEC is supported by an MRC studentship.

PY - 1995/7

Y1 - 1995/7

N2 - Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.

AB - Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.

KW - Autoantibodies

KW - Heat shock proteins

KW - Mrl/lpr mouse

KW - SLE

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Increased levels of antibodies to heat shock proteins with increasing age in MRL/MP-LPR/LPR mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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