TY - JOUR
T1 - Increased risk of asthma at age 10 years for children sensitized to multiple allergens
AU - Havstad, Suzanne L.
AU - Sitarik, Alexandra
AU - Kim, Haejin
AU - Zoratti, Edward M.
AU - Ownby, Dennis
AU - Johnson, Christine Cole
AU - Wegienka, Ganesa
N1 - Funding Information:
Funding: This study is funded by the National Institutes of Health (AI110450, HL113010, AI089473, AI050681). The funder had no role in any part of the study (design, execution, analyses, or writing).
Publisher Copyright:
© 2021 American College of Allergy, Asthma & Immunology
PY - 2021/10
Y1 - 2021/10
N2 - Background: Childhood sensitization patterns have been previously found to be related to variable risk of early life allergic disease in several birth cohorts. Objective: To determine whether these risks persist into later childhood. Methods: In the birth cohort of the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study, previous latent class analysis based on sensitization to 10 allergens found the following 4 early life sensitization patterns at age 2 years: “highly sensitized,” “milk/egg dominated,” “peanut and inhalant(s),” and “low to no sensitization.” At an age 10 study-specific visit, children were evaluated by an allergist for current asthma and atopic dermatitis through a physical examination and interviews with the child and parent or guardian. Total and specific immunoglobulin E (IgE), spirometry, and methacholine challenge were also completed. Results: Compared with children sensitized to none or 1 allergen, children sensitized to 4 or more food and inhalant allergens at age 2 had the highest risk of current asthma (relative risk [RR], 4.42; 95% confidence interval [CI], 2.58-7.59; P < .001) and bronchial hyperresponsiveness (RR, 1.77; 95% CI, 1.29-2.42; P < .001). In addition, they had the highest levels of total IgE (geometric mean, 800 IU/mL; 95% CI, 416-1536) among the 4 groups. Risk of current atopic dermatitis did not depend on pattern of sensitization but remained increased for children with any sensitization (RR, 2.23; 95% CI, 1.40-3.55; P < .001). No differences in spirometry (forced expiratory volume in 1 second, forced expiratory flow between 25% and 75%, and forced expiratory volume in 1 second/forced vital capacity) were identified. Conclusion: The previously reported importance of a specific pattern of sensitization in early life (sensitization to ≥4 inhalant and food allergens) continues to be associated with an increased risk of asthma, bronchial hyperresponsiveness, and high total IgE at age 10 years.
AB - Background: Childhood sensitization patterns have been previously found to be related to variable risk of early life allergic disease in several birth cohorts. Objective: To determine whether these risks persist into later childhood. Methods: In the birth cohort of the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study, previous latent class analysis based on sensitization to 10 allergens found the following 4 early life sensitization patterns at age 2 years: “highly sensitized,” “milk/egg dominated,” “peanut and inhalant(s),” and “low to no sensitization.” At an age 10 study-specific visit, children were evaluated by an allergist for current asthma and atopic dermatitis through a physical examination and interviews with the child and parent or guardian. Total and specific immunoglobulin E (IgE), spirometry, and methacholine challenge were also completed. Results: Compared with children sensitized to none or 1 allergen, children sensitized to 4 or more food and inhalant allergens at age 2 had the highest risk of current asthma (relative risk [RR], 4.42; 95% confidence interval [CI], 2.58-7.59; P < .001) and bronchial hyperresponsiveness (RR, 1.77; 95% CI, 1.29-2.42; P < .001). In addition, they had the highest levels of total IgE (geometric mean, 800 IU/mL; 95% CI, 416-1536) among the 4 groups. Risk of current atopic dermatitis did not depend on pattern of sensitization but remained increased for children with any sensitization (RR, 2.23; 95% CI, 1.40-3.55; P < .001). No differences in spirometry (forced expiratory volume in 1 second, forced expiratory flow between 25% and 75%, and forced expiratory volume in 1 second/forced vital capacity) were identified. Conclusion: The previously reported importance of a specific pattern of sensitization in early life (sensitization to ≥4 inhalant and food allergens) continues to be associated with an increased risk of asthma, bronchial hyperresponsiveness, and high total IgE at age 10 years.
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U2 - 10.1016/j.anai.2021.04.028
DO - 10.1016/j.anai.2021.04.028
M3 - Article
C2 - 33971358
AN - SCOPUS:85107873863
SN - 1081-1206
VL - 127
SP - 441-445.e1
JO - Annals of Allergy, Asthma and Immunology
JF - Annals of Allergy, Asthma and Immunology
IS - 4
ER -