TY - JOUR
T1 - Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment
AU - Jrad-Lamine, Aicha
AU - Henry-Berger, Joelle
AU - Damon-Soubeyrand, Christelle
AU - Saez, Fabrice
AU - Kocer, Ayhan
AU - Janny, Laurent
AU - Pons-Rejraji, Hanae
AU - Munn, David H.
AU - Mellor, Andrew L.
AU - Gharbi, Najoua
AU - Cadet, Rémi
AU - Guiton, Rachel
AU - Aitken, Robert J.
AU - Drevet, Joël R.
PY - 2013/6/20
Y1 - 2013/6/20
N2 - The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1-/- model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1-/- animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.
AB - The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1-/- model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1-/- animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.
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U2 - 10.1371/journal.pone.0066494
DO - 10.1371/journal.pone.0066494
M3 - Article
C2 - 23840489
AN - SCOPUS:84879264731
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 6
M1 - e66494
ER -