TY - JOUR
T1 - Induction of peroxiredoxins in transplanted livers and demonstration of their in vitro cytoprotection activity
AU - Shau, Hungyi
AU - Merino, Alejandro
AU - Chen, Lawrence
AU - Shih, Charles C.Y.
AU - Colquhoun, Steven D.
PY - 2000
Y1 - 2000
N2 - Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.
AB - Peroxiredoxin (Prx)-I and -II belong to a new class of antioxidants. Here, we report that they are induced by ischemia/reperfusion (I/R) in transplanted livers. Hypothesizing that Prxs are induced to protect liver from oxidative damage, we transduced these human genes into murine NIH-3T3 cells. The overexpressed Prxs made the cells more resistant to t- butylhydroperoxide-induced apoptosis. These results indicate that Prx-I and Prx-II are induced by the transplantation process and can protect cells against oxidant damage in tissue culture. Thus, proper genetic manipulations of Prxs may be useful in increasing the success rate of organ transplantation.
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U2 - 10.1089/ars.2000.2.2-347
DO - 10.1089/ars.2000.2.2-347
M3 - Article
C2 - 11229538
AN - SCOPUS:0033918405
SN - 1523-0864
VL - 2
SP - 347
EP - 354
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 2
ER -