Induction of Tumor Necrosis Factor during Extracorporeal Blood Purification

Gerhard Lonnemann, Jos W.m. Van Der Meer, Joseph G. Cannon, Charles A. Dinarello, Karl M. Koch, Céline Granolleras, Gerard Deschodt, Stanley Shaldon

Research output: Contribution to journalLetterpeer-review

54 Scopus citations


To the Editor: Recent studies have shown that blood monocytes become activated during regular hemodialysis and produce interleukin-1.1 2 3 Monocyte products such as interleukin-1 are thought to contribute to both the short-term and long-term changes that are observed with hemodialysis and, to a lesser extent, with hemofiltration.4 We now describe a patient who became acutely ill during a hemofiltration procedure that was associated with a markedly elevated plasma level of tumor necrosis factor. A 21-year-old woman with end-stage renal disease due to interstitial nephritis had received over 650 uneventful treatments using post-dilutional hemofiltration over the previous five years. Two weeks earlier,…

Original languageEnglish (US)
Pages (from-to)963-964
Number of pages2
JournalNew England Journal of Medicine
Issue number15
StatePublished - Oct 8 1987
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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