Infections in patients with gynecological malignancies: Prevention and management

Shivani Singh, Rodger David MacArthur

Research output: Chapter in Book/Report/Conference proceedingChapter


Infections in patients with gynecological malignancies are frequent and a major cause of death and prolonged hospitalization. The patient with cancer is a compromised host and has increased susceptibility to infections due to the tumor itself and also due to therapeutic modalities such as extensive surgical procedures, radiation, and cytotoxic chemotherapy. Infections related to chemotherapy per se are less pronounced than those seen in patients with leukemia, lymphoma, and bone marrow transplantation who have prolonged neutropenia ranging from 1 to 4 weeks. Neutropenia in gynecological malignancy patients lasts approximately for 3 days and therefore infections related to febrile neutropenia are limited. In fact, chemotherapy did not increase the risk of wound complications in this population despite efforts to begin chemotherapy as soon as possible postcytoreductive surgery in one analysis performed in 1992.

Original languageEnglish (US)
Title of host publicationChemotherapy for Gynecological Neoplasms
Subtitle of host publicationCurrent Therapy and Novel Approaches
PublisherCRC Press
Number of pages17
ISBN (Electronic)9781420030990
ISBN (Print)9780824754181
StatePublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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