TY - JOUR
T1 - Inflammation in kidney repair
T2 - Mechanism and therapeutic potential
AU - Fu, Ying
AU - Xiang, Yu
AU - Li, Honglin
AU - Chen, Anqun
AU - Dong, Zheng
N1 - Funding Information:
The work was supported partly by grants from the National Natural Science Foundation of China ( 81720108008 , 82090024 ), the National Key R&D Program of China ( 2020YFC2005000 ), and the Fundamental Research Funds for the Central Universities of Central South University ( 2021zzts0392 ).
Publisher Copyright:
© 2022
PY - 2022/9
Y1 - 2022/9
N2 - The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when injury is severe or persistent, the repair is incomplete or maladaptive and may lead to chronic kidney disease (CKD). Maladaptive kidney repair involves multiple cell types and multifactorial processes, of which inflammation is a key component. In the process of inflammation, there is a bidirectional interplay between kidney parenchymal cells and the immune system. The extensive and complex crosstalk between renal tubular epithelial cells and interstitial cells, including immune cells, fibroblasts, and endothelial cells, governs the repair and recovery of the injured kidney. Further research in this field is imperative for the discovery of biomarkers and promising therapeutic targets for kidney repair. In this review, we summarize the latest progress in the immune response and inflammation during maladaptive kidney repair, analyzing the interaction between immune cells and intrinsic kidney cells, pointing out the potentialities of inflammation-related pathways as therapeutic targets, and discussing the challenges and future research prospects in this field.
AB - The kidney has a remarkable ability of repair after acute kidney injury (AKI). However, when injury is severe or persistent, the repair is incomplete or maladaptive and may lead to chronic kidney disease (CKD). Maladaptive kidney repair involves multiple cell types and multifactorial processes, of which inflammation is a key component. In the process of inflammation, there is a bidirectional interplay between kidney parenchymal cells and the immune system. The extensive and complex crosstalk between renal tubular epithelial cells and interstitial cells, including immune cells, fibroblasts, and endothelial cells, governs the repair and recovery of the injured kidney. Further research in this field is imperative for the discovery of biomarkers and promising therapeutic targets for kidney repair. In this review, we summarize the latest progress in the immune response and inflammation during maladaptive kidney repair, analyzing the interaction between immune cells and intrinsic kidney cells, pointing out the potentialities of inflammation-related pathways as therapeutic targets, and discussing the challenges and future research prospects in this field.
KW - Acute kidney injury
KW - Adaptive repair
KW - Chronic kidney disease
KW - Inflammation
KW - Maladaptive repair
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U2 - 10.1016/j.pharmthera.2022.108240
DO - 10.1016/j.pharmthera.2022.108240
M3 - Review article
C2 - 35803367
AN - SCOPUS:85134380339
SN - 0163-7258
VL - 237
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 108240
ER -