TY - JOUR
T1 - Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration
T2 - An experimental study in the dog
AU - Stavropoulos, Andreas
AU - Wikesjö, Ulf M E
PY - 2010/6
Y1 - 2010/6
N2 - Objective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration. Material and Methods: Contra-lateral one-wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval. Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5% versus 65% and the bone biomaterial 11.6% versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare. Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.
AB - Objective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration. Material and Methods: Contra-lateral one-wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18-month healing interval. Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5% versus 65% and the bone biomaterial 11.6% versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare. Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre-clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.
KW - Animal
KW - Bovine bone biomaterial
KW - Guided tissue regeneration
KW - Membrane
KW - Periodontal regeneration
KW - Pre-clinical
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U2 - 10.1111/j.1600-051X.2010.01566.x
DO - 10.1111/j.1600-051X.2010.01566.x
M3 - Article
C2 - 20507377
AN - SCOPUS:77952418669
SN - 0303-6979
VL - 37
SP - 534
EP - 543
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 6
ER -