Influence of genetic background on fluoride metabolism in mice

J. G. Carvalho, A. L. Leite, D. Yan, E. T. Everett, Gary M. Whitford, M. A.R. Buzalaf

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A/J and 129P3/J mouse strains have different susceptibilities to dental fluorosis, due to their genetic backgrounds. This study tested whether these differences are due to variations in water intake and/ or F metabolism. A/J (susceptible to dental fluorosis) and 129P3/J mice (resistant) received drinking water containing 0, 10, or 50 ppm F. Weekly F intake, excretion and retention, and terminal plasma and femur F levels were determined. Dental fluorosis was evaluated clinically and by quantitative fluorescence (QF). Data were tested by two-way ANOVA. Although F intakes by the strains were similar, excretion by A/J mice was significantly higher due to greater urinary F excretion, which resulted in lower plasma and femur F levels. Compared with 129P3/J mice given 50 ppm F, significantly higher QF scores were recorded for A/J mice. In conclusion, these strains differ with respect to several features of F metabolism, and amelogenesis in the 129P3/J strain seems to be unaffected by high F exposure.

Original languageEnglish (US)
Pages (from-to)1054-1058
Number of pages5
JournalJournal of Dental Research
Issue number11
StatePublished - Nov 2009


  • Bone
  • Dental fluorosis
  • Fluoride metabolism
  • Genetic susceptibility/resistance
  • Inbred mouse strains

ASJC Scopus subject areas

  • Dentistry(all)


Dive into the research topics of 'Influence of genetic background on fluoride metabolism in mice'. Together they form a unique fingerprint.

Cite this