Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice

C. C. Hedrick, L. W. Castellani, C. H. Warden, D. L. Puppione, A. J. Lusis

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


The role of apolipoprotein A-II (apoA-II) in the metabolism of high density lipoproteins (HDL) is poorly understood. Previous studies of naturally occurring variations of apoA-II in mice have, however, suggested that apoA-II expression influences HDL size and concentration. We now provide definitive evidence of this using transgenic mice overexpressing mouse apoA- II. Thus, as compared with nontransgenic littermates, transgenic mice possessing 4-fold elevations of apoA-II mRNA and 2-3-fold elevations in plasma apoA-II levels exhibited more than a 2-fold increase in HDL levels as well as about a 25% increase in average HDL diameter. Overexpression of mouse apoA-II also resulted in a substantial decrease in the levels of apolipoprotein E associated with HDL, suggesting that apoA-II can displace apoE from HDL. The apoA-II transgenic mice also exhibited a 2-4-fold increase in plasma very low density and low density lipoprotein-cholesterol levels, suggesting novel interactions among the classes of plasma lipoproteins.

Original languageEnglish (US)
Pages (from-to)20676-20682
Number of pages7
JournalJournal of Biological Chemistry
Issue number27
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice'. Together they form a unique fingerprint.

Cite this