TY - JOUR
T1 - Inhibiting effect of cytotoxic bromine-containing compounds from sponges (Aplysinidae) on Na+-K+-ATPase activity
AU - Gorshkov, B. A.
AU - Gorshkova, I. A.
AU - Makarieva, T. N.
AU - Stonik, V. A.
PY - 1982
Y1 - 1982
N2 - -The bromine-containing compounds from sponges of the Aplysinidae family inhibit, in vitro, the Na+-K+-ATPase activity of the rat brain microsomal fraction. The extent of inhibition is dependent on concentration and chemical structure of the compounds. The substances containing the dienone fragment, such as 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-acetamide (IV), 3,5-dibromo-1-acetoxy-4-oxo-2,5-cyclohexadien-1-acetonitrile (V) and 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-ethylacetate (VI), are powerful inhibitors of Na+-K+-ATPase.
AB - -The bromine-containing compounds from sponges of the Aplysinidae family inhibit, in vitro, the Na+-K+-ATPase activity of the rat brain microsomal fraction. The extent of inhibition is dependent on concentration and chemical structure of the compounds. The substances containing the dienone fragment, such as 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-acetamide (IV), 3,5-dibromo-1-acetoxy-4-oxo-2,5-cyclohexadien-1-acetonitrile (V) and 3,5-dibromo-1-hydroxy-4-oxo-2,5-cyclohexadien-1-ethylacetate (VI), are powerful inhibitors of Na+-K+-ATPase.
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U2 - 10.1016/0041-0101(82)90113-1
DO - 10.1016/0041-0101(82)90113-1
M3 - Article
C2 - 6131547
AN - SCOPUS:0020366063
SN - 0041-0101
VL - 20
SP - 1092
EP - 1094
JO - Toxicon
JF - Toxicon
IS - 6
ER -