Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata

Irina A. Gorshkova; Boris A. Gorshkov; Sergey A. Fedoreev; Olga P. Shestak; Vyacheslav L. Novikov; Valentin A. Stonik

doi:10.1016/S0742-8413(98)10084-1

Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata

Irina A. Gorshkova, Boris A. Gorshkov, Sergey A. Fedoreev, Olga P. Shestak, Vyacheslav L. Novikov, Valentin A. Stonik

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata, was found to be a powerful inhibitor of the rat brainstem and of the rat brain cortex Na⁺, K⁺-ATPases and the rabbit muscle sarcoplasmic reticulum Ca2⁺-ATPase with I₅₀ values of 7.0 x 10^-7, 1.3 x 10^-6 and 2.5 x 10^-6 M, respectively. Halenaquinol also inhibited K⁺-phosphatase activity of the rat brain cortex Na⁺, K⁺-ATPase with an I₅₀ value of 3 x 10^-6 M. Ouabain-insensitive Mg²⁺-ATPase activity of the microsomal fraction of the rat brain cortex was weakly inhibited by halenaquinol. Inhibition was irreversible, dose- and time-dependent. Naphthohydroquinone fragment in structures of halenaquinol, related natural and model compounds was very important for an inhibiting effect.

Original language	English (US)
Pages (from-to)	93-99
Number of pages	7
Journal	Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
Volume	122
Issue number	1
DOIs	https://doi.org/10.1016/S0742-8413(98)10084-1
State	Published - Jan 1999
Externally published	Yes

Keywords

Ca2-ATPase
Halenaquinol
Inhibition
K-ATPase
Marine organisms
Na
Petrosia seriata
Rat brain
Sarcoplasmic reticulum
Sponge natural products

ASJC Scopus subject areas

Immunology
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0742-8413(98)10084-1

Cite this

Gorshkova, I. A., Gorshkov, B. A., Fedoreev, S. A., Shestak, O. P., Novikov, V. L., & Stonik, V. A. (1999). Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata. Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, 122(1), 93-99. https://doi.org/10.1016/S0742-8413(98)10084-1

Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata. / Gorshkova, Irina A.; Gorshkov, Boris A.; Fedoreev, Sergey A. et al.
In: Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, Vol. 122, No. 1, 01.1999, p. 93-99.

Research output: Contribution to journal › Article › peer-review

Gorshkova, IA, Gorshkov, BA, Fedoreev, SA, Shestak, OP, Novikov, VL & Stonik, VA 1999, 'Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata', Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, vol. 122, no. 1, pp. 93-99. https://doi.org/10.1016/S0742-8413(98)10084-1

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abstract = "Halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata, was found to be a powerful inhibitor of the rat brainstem and of the rat brain cortex Na+, K+-ATPases and the rabbit muscle sarcoplasmic reticulum Ca2+-ATPase with I50 values of 7.0 x 10-7, 1.3 x 10-6 and 2.5 x 10-6 M, respectively. Halenaquinol also inhibited K+-phosphatase activity of the rat brain cortex Na+, K+-ATPase with an I50 value of 3 x 10-6 M. Ouabain-insensitive Mg2+-ATPase activity of the microsomal fraction of the rat brain cortex was weakly inhibited by halenaquinol. Inhibition was irreversible, dose- and time-dependent. Naphthohydroquinone fragment in structures of halenaquinol, related natural and model compounds was very important for an inhibiting effect.",

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Inhibition of membrane transport ATPases by halenaquinol, a natural cardioactive pentacyclic hydroquinone from the sponge Petrosia seriata

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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