Abstract
The effects of the clinical preparation of ketamine, Ketalar and its preservative, benzethonium chloride on [3H]5-hydroxytryptamine uptake were studied using rat brain synaptosomes. Ketalar caused a concentration-dependent inhibition of substrate uptake by the high affinity transport site (I50 = 20.2 ± 2.75 μM) while benzethonium chloride had no effect. Kinetic analysis indicated the inhibition to be competitive with serotonin; the apparent k(m) (54 nM) was increased nearly two-fold at 10 μM ketamine. This action may represent a mechanism involved in ketamine anesthesia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-132 |
| Number of pages | 4 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 62 |
| Issue number | 1 |
| State | Published - Jan 1 1988 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)