Initiation ofTCR phosphorylation and signal transduction

Nicholas R.J. Gascoigne; Javier Casas; Joanna Brzostek; Vasily Rybakin

doi:10.3389/fimmu.2011.00072

Initiation ofTCR phosphorylation and signal transduction

Nicholas R.J. Gascoigne, Javier Casas, Joanna Brzostek, Vasily Rybakin

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Recent data with CD8+T cells show that the initial phase ofT cell receptor (TCR) binding to MHC-peptide (MHCp) is quickly followed by a second, stronger, binding phase represent- ing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the boundTCR before the co-receptor binds to MHCp?

Original language	English (US)
Article number	Article 72
Journal	Frontiers in immunology
Volume	2
Issue number	DEC
DOIs	https://doi.org/10.3389/fimmu.2011.00072
State	Published - 2011
Externally published	Yes

Keywords

CD8
Fyn
Lck
Src-family kinases
T cell receptor

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2011.00072

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title = "Initiation ofTCR phosphorylation and signal transduction",

abstract = "Recent data with CD8+T cells show that the initial phase ofT cell receptor (TCR) binding to MHC-peptide (MHCp) is quickly followed by a second, stronger, binding phase represent- ing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the boundTCR before the co-receptor binds to MHCp?",

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AU - Gascoigne, Nicholas R.J.

AU - Casas, Javier

AU - Brzostek, Joanna

AU - Rybakin, Vasily

PY - 2011

Y1 - 2011

N2 - Recent data with CD8+T cells show that the initial phase ofT cell receptor (TCR) binding to MHC-peptide (MHCp) is quickly followed by a second, stronger, binding phase represent- ing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the boundTCR before the co-receptor binds to MHCp?

AB - Recent data with CD8+T cells show that the initial phase ofT cell receptor (TCR) binding to MHC-peptide (MHCp) is quickly followed by a second, stronger, binding phase represent- ing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the boundTCR before the co-receptor binds to MHCp?

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KW - T cell receptor

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Initiation ofTCR phosphorylation and signal transduction

Abstract

Keywords

ASJC Scopus subject areas

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