Interleukin-6 in the fever and multiorgan crisis of pheochromocytoma

Abu Salahuddin, Theresa Rohr-Kirchgraber, Raja Shekar, Burton West, Joseph Loewenstein

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


A 31-y-old black man with neurofibromatosis, alcoholism and hypertension was admitted because of abdominal pain, hematemesis and cough. In the hospital he had prolonged fever and developed a multiorgan crisis. Despite thorough investigation, no infectious cause for fever was found. Urinary catecholamines and metabolites were markedly elevated. Computerized tomography revealed a mass abutting the left kidney. A diagnosis of pheochromocytoma was made, and as soon as treatment with phenoxybenzamine and propranolol was begun, the fever resolved. Serum interleukin-6 (IL-6) concentration was initially elevated, decreased after the start of adrenergic blockade, and gradually fell to an undetectable level after surgery. These observations suggest that interleukin-6 might have been causally related to the patient's fever and possibly the multiorgan crisis.

Original languageEnglish (US)
Pages (from-to)640-642
Number of pages3
JournalScandinavian Journal of Infectious Diseases
Issue number6
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases


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