Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats

Xin Hong Zhu, Hua Cheng Yan, Jie Zhang, Hong Da Qu, Xing Sheng Qiu, Liang Chen, Shu Ji Li, Xiong Cao, Jonathan C. Bean, Long Hua Chen, Xi He Qin, Ji Hong Liu, Xiao Chun Bai, Lin Mei, Tian Ming Gao

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177 Scopus citations


Increasing evidence indicates that stimulating hippocampal neurogenesis could provide novel avenues for the treatment of depression, and recent studies have shown that in vitro neurogenesis is enhanced by hypoxia. The aim of this study was to investigate the potential regulatory capacity of an intermittent hypobaric hypoxia (IH) regimen on hippocampal neurogenesis and its possible antidepressant-like effect. Here, we show that IH promotes the proliferation of endogenous neuroprogenitors leading to more newborn neurons in hippocampus in adult rats. Importantly, IH produces antidepressant-like effects in multiple animal models screening for antidepressant activity, including the forced swimming test, chronic mild stress paradigm, and novelty-suppressed feeding test. Hippocampal x-ray irradiation blocked both the neurogenic and behavioral effects of IH, indicating that IH likely produces antidepressant-like effects via promoting neurogenesis in adult hippocampus. Furthermore, IH stably enhanced the expression of BDNF in hippocampus; both the antidepressant-like effect and the enhancement of cell proliferation induced by IH were totally blocked by pharmacological and biological inhibition of BDNF-TrkB (tyrosine receptor kinase B) signaling, suggesting that the neurogenic and antidepressant-like effects of IH may involve BDNF signaling. These observations might contribute to both a better understanding of physiological responses to IH and to developing IH as a novel therapeutic approach for depression.

Original languageEnglish (US)
Pages (from-to)12653-12663
Number of pages11
JournalJournal of Neuroscience
Issue number38
StatePublished - Sep 22 2010

ASJC Scopus subject areas

  • General Neuroscience


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