Intravascular ultrasound imaging of vascular responsiveness in isolated perfused canine arteries

Mark W. Wilson, R. Clinton Webb, M. Victoria Marx, Charles R. Meyer, Marsha A. Gallagher, Staci L. Haarer, Andrew J. Buda, David M. Williams

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We investigated the feasibility of using intravascular ultrasound imaging to analyze vascular physiology in various arterial beds. Canine superficial femoral, external iliac, and common carotid arteries were harvested and suspended and perfused in a bath of oxygenated, heated, physiologic salt solution. A 6-Fr, 20-MHz ultrasound imaging catheter was inserted into the lumen of the arteries and serial images were acquired after bolus injections of either serotonin or normal saline into the extravascular bathing medium. Serotonin resulted in a significant time and dose-dependent decrease in cross-sectional area in muscular femoral arteries (P < .001): –5.2% with 10–8 M serotonin, –15% with 10–7 M, and –28% with 10–6 M. Historically transitional iliac arteries demonstrated less marked changes, while elastic carotid arteries demonstrated no significant changes. Our results indicate that intravascular ultrasound may be used to quantify and differentiate responses to vasoconstrictive agents in different vascular beds.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalInvestigative Radiology
Issue number3
StatePublished - Mar 1991
Externally publishedYes


  • Canine arteries
  • Elastin
  • Intravascular ultrasound imaging
  • Serotonin
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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