Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline

James B. Appel, Patrick M. Callahan

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


In order to further evaluate the extent to which particular 5-HT receptor subtypes (5-HT1, 5-HT2) might be involved in the behavioral effects of hallucinogenic drugs, rats were trained to discriminate mescaline (10 mg/kg i.p.) from saline and were given substitution (generalization) and combination (antagonism) tests with putatively selective serotonergic and related neuroactive compounds. The mescaline cue generalized to relatively high doses of the 5-HT2 agonists, 2,5-dimethoxy-4-methylamphetamine (DOM), LSD and psilocybin; the extent of generalization to 5-HT1 agonists (8-hydroxy-2-[diethylamino]tetralin (8-OHDPAT), RU-24969 and 8-hydroxy-2-[di-n-propylamino]tetralin (TFMPP) was unclear. Combinations of the training drug and sufficiently high doses of 5-HT2 antagonists (ketanserin, LY-53857, pirenperone) were followed by saline-lever responding; less selective central 5-HT (metergoline), and DA (SCH-23390, haloperidol) antagonists, did not block the mescaline cue. These data suggest that 5-HT2 receptors are involved in the stimulus properties of mescaline.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number1
StatePublished - Jan 2 1989
Externally publishedYes


  • 5-HT receptors
  • 5-HT receptors
  • 5-HT receptors
  • Drug discrimination
  • Hallucinogens
  • Mescaline

ASJC Scopus subject areas

  • Pharmacology


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