Iron chelation inhibits osteoclastic differentiation in vitro and in Tg2576 mouse model of Alzheimer's disease

Keyphrases

• Age-dependent 20%
• Alzheimer's Disease 100%
• Alzheimer's Disease Model 100%
• Amyloid Precursor Protein 20%
• Animal Disease Models 20%
• APPswe 60%
• Bone Marrow Macrophages 80%
• Bone Mass 20%
• Chelation Effect 20%
• Cortical Bone 20%
• Deferoxamine 20%
• Differentiation in Vitro 100%
• Disease-associated 20%
• Hip Fracture 20%
• In Vitro Study 20%
• In Vivo Applications 20%
• Inhibitory Effect 20%
• Intracellular Iron 20%
• Iron Chelation 100%
• Iron Chelator 40%
• Iron Export 20%
• Iron Levels 20%
• Low Bone Mineral Density 20%
• Metal Chelation 20%
• Neuropathology 20%
• Osteoblast Differentiation 20%
• Osteoclast 20%
• Osteoclast Activation 20%
• Osteoclast Differentiation 20%
• Osteoclast Formation 20%
• Osteoclastic Differentiation 100%
• Potential Therapeutic Strategies 20%
• Potential Therapeutics 20%
• Tg2576 40%
• Tg2576 Mice 100%
• Therapeutic Value 20%
• Trabecular Bone 20%
• Wild Mice 20%

Biochemistry, Genetics and Molecular Biology

• Amyloid Precursor Protein 25%
• Animal Disease Model 25%
• Bone Density 25%
• Bone Mass 25%
• Chelation 25%
• In Vitro Study 25%
• Iron Chelation 100%
• Macrophage 100%
• Mouse Model 100%
• Osteoblast 25%
• Osteoclast 25%
• Osteoclast Activity 25%
• Osteoclastogenesis 50%
• Tg2576 Mouse 100%
• Wild Type 25%
• Wild Type Mouse 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Alzheimer's Disease 100%
• Amyloid Precursor Protein 16%
• Deferoxamine 16%
• Hip Fracture 16%
• Iron Chelating Agent 33%
• Mouse Model 100%
• Tg2576 Mouse 100%
• Wild Type Mouse 16%