Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation

Eugene Kim; Ming Jiang; Huachao Huang; Yongchun Zhang; Natalie Tjota; Xia Gao; Jacques Robert; Nikesha Gilmore; Lin Gan; Jianwen Que

doi:10.1016/j.devcel.2019.11.002

Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation

Eugene Kim, Ming Jiang, Huachao Huang, Yongchun Zhang, Natalie Tjota, Xia Gao, Jacques Robert, Nikesha Gilmore, Lin Gan, Jianwen Que

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The disease mechanism of the birth defect esophageal atresia with or without trachea-esophageal fistula remains largely unknown. Kim et al. used Xenopus and mouse genetic models to show that an Isl1-Nkx2.1 axis regulates a midline epithelial progenitor cell population that orchestrates trachea-esophageal separation.

Original language	English (US)
Pages (from-to)	675-683.e4
Journal	Developmental Cell
Volume	51
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2019.11.002
State	Published - Dec 16 2019
Externally published	Yes

Keywords

EA/TEF
Isl1
Nkx2.1
Sox2
esophageal atresia
foregut separation
lobation
lung development

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.11.002

Cite this

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title = "Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation",

abstract = "The disease mechanism of the birth defect esophageal atresia with or without trachea-esophageal fistula remains largely unknown. Kim et al. used Xenopus and mouse genetic models to show that an Isl1-Nkx2.1 axis regulates a midline epithelial progenitor cell population that orchestrates trachea-esophageal separation.",

keywords = "EA/TEF, Isl1, Nkx2.1, Sox2, esophageal atresia, foregut separation, lobation, lung development",

author = "Eugene Kim and Ming Jiang and Huachao Huang and Yongchun Zhang and Natalie Tjota and Xia Gao and Jacques Robert and Nikesha Gilmore and Lin Gan and Jianwen Que",

note = "Funding Information: We thank Tina Martin and Francisco De Jesus Andino for animal husbandry. We are grateful for the funds provided by NIH ( R01HL132996 , R01DK100342 [J.Q.], and R24AI059830 [J.R.]), and the National Science Foundation (J.R.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "16",

doi = "10.1016/j.devcel.2019.11.002",

language = "English (US)",

volume = "51",

pages = "675--683.e4",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "6",

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T1 - Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation

AU - Kim, Eugene

AU - Jiang, Ming

AU - Huang, Huachao

AU - Zhang, Yongchun

AU - Tjota, Natalie

AU - Gao, Xia

AU - Robert, Jacques

AU - Gilmore, Nikesha

AU - Gan, Lin

AU - Que, Jianwen

N1 - Funding Information: We thank Tina Martin and Francisco De Jesus Andino for animal husbandry. We are grateful for the funds provided by NIH ( R01HL132996 , R01DK100342 [J.Q.], and R24AI059830 [J.R.]), and the National Science Foundation (J.R.). Publisher Copyright: © 2019 Elsevier Inc.

PY - 2019/12/16

Y1 - 2019/12/16

N2 - The disease mechanism of the birth defect esophageal atresia with or without trachea-esophageal fistula remains largely unknown. Kim et al. used Xenopus and mouse genetic models to show that an Isl1-Nkx2.1 axis regulates a midline epithelial progenitor cell population that orchestrates trachea-esophageal separation.

AB - The disease mechanism of the birth defect esophageal atresia with or without trachea-esophageal fistula remains largely unknown. Kim et al. used Xenopus and mouse genetic models to show that an Isl1-Nkx2.1 axis regulates a midline epithelial progenitor cell population that orchestrates trachea-esophageal separation.

KW - EA/TEF

KW - Isl1

KW - Nkx2.1

KW - Sox2

KW - esophageal atresia

KW - foregut separation

KW - lobation

KW - lung development

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SN - 1534-5807

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Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation

Abstract

Keywords

ASJC Scopus subject areas

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